Open AccessCross-Linked Ionic Polysaccharides: Insights from the Structure to Stimuli-Sensitive Drug Delivery System Applications
Author(s) -
Tuhin Ghosh,
Suman Mukherjee
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23722
Subject(s) - polysaccharide , drug delivery , chemistry , ionic bonding , drug , nanotechnology , polymer , biophysics , chemical engineering , ion , biochemistry , organic chemistry , pharmacology , materials science , medicine , engineering , biology
The review provides an insight regarding the state of the art of cross-linked ionic polysaccharides,which are a part of common drug delivery systems, which are involved in the regulation of release ofdrug in specific required sites. The changes in pH, ion concentration, wavelength, redox potential,temperature, electric and magnetic field intensity are the stimuli sensitive functions, which play a majorroles. Due to their high reproducibility and better characterization from natural resources, thepolysaccharides remains as a point of interest for compiling many stimuli-responsive drug deliverysystems. The hydrogel networks are formed from ready cross-linking of ionic polysaccharides, subjectto control of internal and external variables. These hydrogel networks become operative for drugrelease on-off through complex mechanisms. The polysaccharide-based drug delivery systems arenow responsive to different hybrids, composites and grafted polymers with a broad range of stimulifunctions.