Open AccessIn vitro Assessment of Antioxidant and Anticancer Potential of Flavonoid Glycosides of Glinus oppositifolius (L.) Aug. DC.
Author(s) -
K. Kannan,
Dhandayuthapani Kandavel,
P. Rajalakshmi
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23664
Subject(s) - chemistry , flavonoid , phytochemical , rutin , antioxidant , glycoside , traditional medicine , nutraceutical , pharmacology , biochemistry , organic chemistry , biology , medicine
Development of unbalanced state of free radicals and their elimination in the body is the reason forincrease in different types of chronic diseases including cancer. A better natural supplement to playrole of antioxidants to combat the free radicals and to reduce the risk of cancer is in high demand. Thiscurrent research work focused on identifying such a potent phytocompounds from Glinus oppositifolius(L.) Aug. DC. The active compounds of the aerial parts of the plant have been extracted using methanoland the phytochemical analysis was carried out using qualitative tests, FTIR and GC-MS. The plantextract found to contain range of phyto compounds with good amounts of flavonoid and xylofuranoside.Flavonoid glycoside from the plant extract has been partially purified through chromatography andtested for efficiency against free radicals through in vitro antioxidant assays. The partially purifiedcompound showed good antioxidant activity equivalent to 62.12 to 63.35 μg of rutin standard. Furthercytotoxic nature of the flavonoid glycoside was also assessed against breast cancer MDA-MB-231cell line. The tested compound has shown cancerous cell controlling ability (76.68% cell death in 24h). The immense antioxidant and anticancer potential of flavonoid glycosides of G. oppositifoliuscould be utilized as a good source of natural, antioxidant supplement under nutraceuticals to preventoxidative-stress-related disorders and also as therapeutic compound to cure cancer underpharmaceuticals.