Open AccessGreen Synthesis and in vitro Anti-Tubercular Activity of Monometallic and Bimetallic Oxide Nanoparticles
Author(s) -
Vidya Kalyankar,
Varsha S. Honmore,
Shobha Waghmode,
Sharada P. Dagade
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23661
Subject(s) - bimetallic strip , chemistry , nuclear chemistry , nanoparticle , oxide , cytotoxicity , antibacterial activity , in vitro , bacteria , metal , nanotechnology , organic chemistry , biochemistry , materials science , biology , genetics
Tuberculosis (TB) is an infectious disease with limited drugs and currently the research is focused onits prevention, diagnosis and treatment. In recent studies, it is observed that the therapeutics approachof tuberculosis is more convenient to use nanoparticles for the treatment. With this regard, we foccussedpresent study towards modified green synthesis of monometallic oxide and bimetallic Cu-Zn andCu-Mn oxide nanoparticles using Ficus religosa extract. All the synthesized bimetallic Cu-Zn oxideand Cu-Mn oxide nanoparticles were characterized by powdered XRD, FTIR, FE-SEM with EDSreports and ESR spectra. All the monometallic and bimetallic oxide nanoparticles were tested for invitro anti-tubercular, antibacterial and cytotoxic activity. The Cu-Mn oxide nanoparticles showedpromising result with IC50 = 6.27 μg/mL, MIC = 53.61 μg/mL and IC50 = 8.81 μg/mL, MIC= 54.82μg/mL against M. tuberculosis H37Ra at dormant state and active state, respectively. Whereas Cu-Znand Cu-Mn oxide nanoparticles showed moderate effect against M. tuberculosis H37Ra. On the otherhand, all these nanoparticles were inactive against two Gram-positive and two Gram-negative bacterialstrains with low cytotoxicity.