Open AccessEvaluation of Cu-Ag Bimetallic Nanoalloys as Antibacterial, Antidiabetic, Anticancerous Drug Biosynthesized from Curcuma aromatica
Author(s) -
Jasmine Jacob,
T. Augustine Arul Prasad,
B. Scholastica Mary Vithiya,
Bindhu Thomas,
R. Vasanthi
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23651
Subject(s) - bimetallic strip , chemistry , nuclear chemistry , antibacterial activity , antimicrobial , scanning electron microscope , transmission electron microscopy , curcuma , nanoparticle , aqueous solution , metal , pharmaceutics , bacteria , aqueous extract , drug delivery , nanotechnology , organic chemistry , materials science , traditional medicine , medicine , pharmacology , biology , composite material , genetics
Drug resistant strains are formed due to unsuitable uses of antibiotics and insufficient check of infections.In present years, due to the extensive antimicrobial properties, metallic nanoparticles andmetallo-pharmaceutics are highly proposed. Therefore, the synthesis of bimetallic nanoparticles areexploring towards the evolution of more productive amalgamative antimicrobials composed of combinedmetals. In this study, the green synthesis of Cu-Ag bimetallic nano-alloys using aqueous extract fromthe leaves of Curcuma aromatica is carried out. Synthesized Cu-Ag nano-alloys were characterizedby UV-visible spectroscopy, scanning electron microscope (FE-SEM), transmission electron microscope(TEM-EDAX), cyclic voltammogram (CV). The characterization studies reveals that the biosynthesisproduced core-shell Cu-Ag nano-alloys with spherical shape and average diameter size of 15 nm. Thesynthesized Cu-Ag nanoalloys exhibited antibacterial activity against both Gram-positive andGram-negative bacteria. The antidiabetic potential of Cu-Ag nanoalloys shows an effective inhibitionagainst α-glucosidase. Anticancerous activity of Cu-Ag nanoalloys indicates its greater efficacy indestroying cancer cells. The biosynthesis of Cu-Ag nanoalloys can be employed in medical andindustrial fields on a large scale with cost reductive method.