Open AccessSynthesis and Structural Studies of N-Maltosylated Aryl Thiobiurets
Author(s) -
Anuja M. Mopari,
Gajanan V. Korpe
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23649
Subject(s) - chemistry , aryl , thiourea , aspergillus niger , staphylococcus aureus , antifungal , escherichia coli , antibacterial activity , antimicrobial , organic chemistry , stereochemistry , combinatorial chemistry , bacteria , microbiology and biotechnology , biochemistry , alkyl , biology , gene , genetics
The derivatives of urea, thiourea and thiosemicarbazide play an important role in medicinal chemistryby influencing various pharmacological activities. The design and development of novel N-maltosideshave emerged as an important class of organic compounds. A series of 1-hepta-O-benzoyl-β-D-Maltosyl-5-aryl-2-4-thiobiurets are described in present work. By mixing hepta-O-benzoyl→D-maltosylisocyanates with various aryl thiocarbamides, 1-hepta-O-benzoyl-β-D-maltosyl-5-aryl-2-4-thiobiuretshave been synthesized. The identities of this newly synthesized 1-hepta-O-benzoyl-β-D-Maltosyl-5-aryl-2-4-thiobiurets were characterized by IR, 1H NMR and mass analyses. The compounds tested forantibacterial activity against a wide range of microorganisms, including Staphylococcus aureus,Escherichia coli, Psudomonas aeruginosa and antifungal activities against Aspergillus niger andTrichoderma. TLC confirmed the activity of these compounds.