Open AccessSynthesis, Characterization and Bioactivity Studies of S-Allyl-β-N-(1-(4-methoxyphenyl)- ethylidene)dithiocarbazate and its Bis-chelated Cu(II), Ni(II) and Zn(II) Complexes
Author(s) -
Nilesh V. Junghare,
Shrikant B. Jagtap,
Rahul R. Jadhav,
Jyoti P. Jadhav
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23635
Subject(s) - chemistry , chelation , ligand (biochemistry) , deprotonation , metal , moiety , medicinal chemistry , stereochemistry , nuclear chemistry , inorganic chemistry , organic chemistry , ion , receptor , biochemistry
The general formula M(mAp-sadtc)2 type of metal complexes (where M = Cu2+, Ni2+, Zn2+) weresynthesized by reaction of S-allyl-β-N-(1-(4-methoxyphenyl)ethylidene)dithiocarbazate ligand[H-(mAp-sadtc)] with metal(II) acetate salts (M = Ni2+, Cu2+ or Zn2+). The bis-chelated metal complexeswere synthesized by subsequent reaction of metal(II) acetate salts and dithiocarbazate ligand in 1:2proportion, respectively. The metal complexes and dithiocarbazate Schiff base were characterized byavailable methods like elemental analysis, 1H NMR, UV-Vis spectroscopy, 13C NMR, FT-IRspectroscopy, molar conductance and magnetic moments. Both nitrogen atoms of azomethine moiety(C=N) and deprotonated thiolate sulfur of dithiocarbazate ligand coordinated to the central metal ionformed five-membered rings on chelation. The synthesized dithiocarbazate ligand [H-(mAp-sadtc)](1) and its bis-chelated M(mAp-sadtc)2 complexes (2-4) were screened for bioactivity against bacterialstrains. The antibacterial results show that the metal(II) complexes exhibited significantly prominentantibacterial activity than dithiocarbazate ligand. Among the synthesized bis-chelated metal complexes,Ni-complex exhibited prominent antibacterial and antifungal activity as compared to other metal(II)complexes and ligand.