Open AccessMechanochemical Synthesis of Biologically Active Transition Metal Complexes of 1H-4,4,6-Trimethyl-3,4-dihydropyrimidine-2-thione
Author(s) -
Pooja Sethi,
Rajshree Khare,
Renuka Choudhary,
Simrat Kaur
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23605
Subject(s) - chemistry , ligand (biochemistry) , molar conductivity , metal , proton nmr , stoichiometry , transition metal , nuclear chemistry , antibacterial activity , fourier transform infrared spectroscopy , mass spectrometry , carbon 13 nmr , inorganic chemistry , stereochemistry , organic chemistry , bacteria , catalysis , biochemistry , physics , receptor , chromatography , quantum mechanics , biology , genetics
A new series of metal complexes using 1H-4,4,6-trimethyl-3,4-dihydro-2-pyrimidinethione (HTMPT)ligand were synthesized mechanochemically and also evaluated for antibacterial and DNAphotocleavage potential. Complexes of 1H-4,4,6-trimethyl-3,4-dihydro-2-pyrimidinethione (HTMPT)[M(tmpt)2(H2O)n] (M = Cu2+, Mn2+, Ni2+, Co2+; n = 2 and M = Zn2+, Cd2+, Pd2+; n = 0) were synthesizedin 1:2 metal ligand ratio. All the metal complexes were characterized by 1H NMR, FTIR, UV-vis,ESI-mass spectrometry, molar conductivity, magnetic and thermal measurements. 1H NMR and IRresults showed that the coordination occurs via N and S forming four-membered cyclic ring. Massspectrum showed the formation of 1:2 metals to ligand stoichiometry. The antibacterial activity ofsynthesized compounds was evaluated by agar well diffusion method. All the synthesized compoundswere evaluated for their DNA nicking activity and found most of metal complexes exhibited goodDNA photocleavage activities.