Open AccessFluoroquinolones Metal Complexes as Potent Antibacterial Agents
Author(s) -
Savita Khatri,
Manoj Kumar,
Harkesh Sehrawat,
S.P. Khatkar,
V.B. Taxak,
Rajesh Kumar
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23600
Subject(s) - ofloxacin , sparfloxacin , norfloxacin , chemistry , gatifloxacin , ciprofloxacin , levofloxacin , antibacterial activity , moxifloxacin , gemifloxacin , metal , enoxacin , pefloxacin , pharmacology , enrofloxacin , combinatorial chemistry , nuclear chemistry , antibiotics , organic chemistry , biochemistry , bacteria , medicine , biology , genetics
In this review article, a brief discussion of fluoroquinolones (FQs) and their tendency to form metalcomplexes is presented. The effect of FQs-M complexes on disease causing microorganisms is alsosummarized. The antibacterial activity of various metal complexes of various fluoroquinolones[norfloxacin (NOR), ciprofloxacin (CIP), levofloxacin (LEVO), ofloxacin (OFL), gemifloxacin (GEMI),gatifloxacin (GATI), moxifloxacin (MOX), enrofloxacin (ENRO), sparfloxacin (SPRX)] is reviewedby comparing zone of inhibition and MIC values of metal complexes. It is found to be eithercorresponding with the parent fluoroquinolone or in some cases their respective metal complexesexhibit stronger antibacterial activity. New approach towards synthesis of FQ-metal complexes hasled to formation of compounds with the anticancer and antiviral activity.