Open AccessStudies on Ethanolic Extract of Brown Seaweed Turbinaria ornata from Coastal Area of Tamil Nadu: In vitro Antioxidant and Anticancer Properties
Author(s) -
Schaugar Azad,
K. Jeyaprakash
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23594
Subject(s) - chemistry , dpph , antioxidant , hydroxyl radical , traditional medicine , ic50 , in vitro , ethanol , food science , biochemistry , medicine
Seaweeds are one of the most diverse bioreserves, including a wide range of bioactive compoundswith various properties and functions. In present study, the antioxidant and anticancer activity ofbrown seaweed Turbinaria ornata was extracted using two different solvents like aqueous and ethanol.Higher concentrations of bioactive compounds were observed in ethanolic extract of T. ornata (EETO)in comparison to aqueous extract of T. ornata (AETO). The ethanolic extract showed potent antioxidantproperties for DPPH and hydroxyl radical scavenging. The IC50 value of the ethanolic extract wasfound to be 48 and 50 μg/mL for DPPH and hydroxyl radical scavenging assay, respectively. Humanbreast adenocarcinoma (MCF-7) cells treated with different concentrations of the ethanolic extractshowed a dose-dependent increase in cell inhibition. The LC50 value of the ethanolic extract wascalculated to be 115.19 μg/mL and cell morphology was observed under an inverted phase-contrastmicroscope. As a result, based on the present findings, it is suggested that T. ornata extract might be apromising antioxidant and anticancer therapeutics.