Open AccessSynthesis, Characterization and Biological Activity of ONO Donor Schiff Base and its Metal Complexes
Author(s) -
Nalini Ramarao,
S. M. Basavarajaiah,
Nagesh Gunavanthrao Yernale,
K. Ramakrishna Reddy
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23592
Subject(s) - chemistry , schiff base , ligand (biochemistry) , metal , methylene , hydrazine (antidepressant) , medicinal chemistry , stereochemistry , artemia salina , hydrazone , cytotoxicity , nuclear chemistry , antibacterial activity , in vitro , polymer chemistry , organic chemistry , bacteria , biochemistry , receptor , toxicity , biology , genetics
A new Schiff base ligand (E)-2-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)-N-(5-methyl-3-phenyl-1H-indol-2-yl)hydrazine carboxamide (L) (3) was synthesized by the reaction ofN-(5-methyl-3-phenyl-1H-indol-2-yl)hydrazinecarboxamide (1) and 7-hydroxy-4-methyl-2-oxo-2Hchromene-8-carbaldehyde (2). The Cu(II), Co(II), Ni(II) and Zn(II) metal complexes (4a-d) weresynthesized and its structural elucidation was done by different spectral techniques. The Schiff base(3) behaves as ONO donor ligand and forms the complexes of the sort [M(L)(Cl)(H2O)2] for Cu(II)(4a) and Zn(II) (4d) and [M(L)2] for Co(II) (4b) and Ni(II) (4c). Compounds (3) and (4a-d) weretested in vitro for antimicrobial action, cytotoxicity property against Artemia salina and anti-tuberculosisassay against Mycobacterium tuberculosis (ATCC 25177). The metal complexes showed very goodbiological activity.