Open AccessSynthesis, Characterization and Biological Evaluation of Some Novel Azo-Imine Compounds
Author(s) -
K. Sunitha,
Smitha M. Nair,
P. Palanisamy
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23591
Subject(s) - chemistry , imine , benzene , semicarbazone , proton nmr , aryl , carbon 13 nmr , medicinal chemistry , ferric , claisen condensation , condensation reaction , antifungal , chloride , organic chemistry , catalysis , medicine , alkyl , dermatology
The oxidative cyclization of thiosemicarbazone (III) synthesized from reaction between substitutedaryl aldehydes (I) with thiosemicarbazide (II) was done using ferric chloride as oxidative agent to get2-amino-5-phenyl-1,3,4-thiadiazole (IV). 2-Amino-5-phenyl-1,3,4-thiadiazole was introduced incondensation reactions with substituted aldehydes to obtain benzylidene imine derivatives (VI)1-5.Further these were treated with sulphanilic acid to give new 2-{[5-phenyl-1,3,4-thiadiazole-2-imino]substituted benzene}diazenyl benzene sulfonic acid derivatives (VII)1-5. These derivatives were furthercharacterized by FT-IR, 1H NMR and 13C NMR spectral studies and were screened for antibacterial,antifungal and antioxidant activities.