Open AccessSynthesis, Characterization and Biological Screening of Novel Imidazolylpyrazole Scaffolds
Author(s) -
JYOTSNA SHARMA,
Hardeep Singh Tuli,
Mayank Kinger,
Ram Pal,
Zahoor Abbas,
Manoj Kumar
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23570
Subject(s) - chemistry , antimicrobial , elemental analysis , carbon 13 nmr , proton nmr , aryl , fourier transform infrared spectroscopy , staphylococcus aureus , pyrazole , nuclear chemistry , combinatorial chemistry , bacteria , organic chemistry , stereochemistry , alkyl , biology , genetics , physics , quantum mechanics
A novel series of 3-(4-aryl)-4-(4,5-diphenyl-1H-imidazol-2-yl)-1-phenyl-1H-pyrazole was synthesized by employing the well-knownDebus-Radziszewski reaction. Structures of all the newly synthesized compounds have been characterized by various spectroscopictechniques viz. FTIR, 1H and 13C NMR, LC-MS and elemental analysis. All these compounds were also screened for antimicrobialpotential against bacterial strains of S. aureus, K. pneumoniae and fungal strains of A. niger and T. rubrum.