Open AccessOne-Pot Synthesis and Characterization of 3,4-Dihydropyrimidin-2(1H)-one Derivatives using Sulphonated Reduced Graphene Oxide Nanoparticles via Biginelli Cyclocondensation and its Cytotoxic Studies
Author(s) -
M. BHASKARA RAO,
Venkateswara Rao Battula
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23543
Subject(s) - chemistry , bromide , urea , graphene , biginelli reaction , proton nmr , oxide , nuclear chemistry , solvent , carbon 13 nmr , methanol , combinatorial chemistry , organic chemistry , nanotechnology , materials science
A facile one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (4a-h) was performed in the presence of sulphonated reduced grapheneoxide nanoparticles (SrGO NPs), using various substituted aromatic aldehydes (1a-h), β-keto ester (2) and urea (3). Methanol solventmediated the reaction, under refluxing conditions. The synthesized SrGO NPs were characterized using XRD, SEM-EDS and Ramanspectroscopic methods. The structural moieties of the organic compounds were confirmed by 1H NMR, 13C NMR, FTIR and Massspectroscopic techniques. The in vitro anticancer activity of the synthesized derivatives (4a-h) was investigated using MTT (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay as per American Type Culture Collection protocol. The cytotoxicstudies were conducted against MCF-7, SKNSH human cells, using doxorubicin as the standard. Majority of the derivatives have exhibitedsuperior anticancer activity.