Open AccessBonding Ability of Isopthalic Acid-bis(thiosemicarbozone) to Manganese and Cobalt Metal Ions: Preparation, Spectral Investigation, Computational and in vitro Antipathogenic Screening
Author(s) -
Shweta Gautam,
Poonam Pipil,
Adarsh Kumar,
. Alka,
J. J. Singh,
RAVIKANT RAVIKANT,
Sonica Singhal,
S. Sagar
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23508
Subject(s) - chemistry , cobalt , manganese , ligand (biochemistry) , metal , metal ions in aqueous solution , nickel , inorganic chemistry , nuclear chemistry , organic chemistry , biochemistry , receptor
Manganese and cobalt complexes have been designed and prepared with a tetradentate ligand i.e.isopthalic acid-bis(thiosemicarbozone) (IPBT), which bind to metal ions via donor atoms present inligand. Different spectroscopic techniques viz. nuclear magnetic resonance, infra red, mass, electronicspin resonance and analytical studies have been used to determine the chemical composition ofsynthesized IPBT and its Mn(II) and Co(II) complexes. The spectroscopic data exposed that IPBTbehaves in a tetradentate (N2S2) mode by having ability to bind with metal ions through N2S2 atoms.An octahedral structure for manganese and cobalt complexes has been suggested on the basis ofspectroscopic as well as analytical studies. The ligand (IPBT) and its metal(II) complexes have beenscreened to determine their antipathogenic activity against some selective microorganisms S. aureus,P. aeruginosa, E. coli, A. niger, M. phasolina and P. glomerata. In this experimental work, well diffusionand poisoned food techniques have been introduced for screening purpose and as standard drugsneomycin and chlorothalonil have been used. Data for antipathogenic screening exposed that metalcomplexes exerted higher activity towards all examined microbes (bacteria and fungi) even than ligand.