Open AccessKinetic Oxidation Studies of Pentoxifylline by N-Chlorosuccinimide in Acidic Medium Using Iridium(III) Chloride as Inhibitor
Author(s) -
Rakesh Patel,
Ram Prakash,
Ritu Bala,
Brijesh Kumar Prajapati,
Rupam Yadav
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23494
Subject(s) - chemistry , activation energy , iridium , entropy of activation , pentoxifylline , reaction rate constant , kinetics , enthalpy , reaction rate , chloride , inorganic chemistry , order of reaction , catalysis , organic chemistry , thermodynamics , medicine , physics , quantum mechanics , pharmacology
In present study, the kinetics and mechanism of oxidation of pentoxifylline (PTX) byN-chlorosuccinimide (NCS) in acidic conditions at 40 ± 0.1 ºC is reported. The reaction depictsfirst-order kinetics in regard to [NCS], [PTX] and [HClO4]. The reaction rate goes on decreasing asthe concentration of iridium(III) chloride is increased. This shows that iridium(III) chloride plays therole of an inhibitor in the reaction under investigation. Nil impact of [Hg(OAc)2], [NHS] and dielectricconstant (D) of the medium on the rate of oxidation of pentoxifylline have been observed. This reactionhas been investigated from 308-323 K and the monitored rate of reaction suggests a direct relationshipbetween temperature and the rate of reaction. From the graph between log k and 1/T, value of activationenergy (Ea) was numerated and more activation parameters like enthalpy of activation (ΔH#), entropyof activation (ΔS#) and free energy of activation (ΔG#) were calculated with the help of activationenergy (Ea). On account of experimentally determined the kinetic orders and activation parameters, amost plausible reaction path has been suggested for the oxidation of pentoxifylline in presence ofIr(III) as an inhibitor.