Open AccessSynthesis, Anticancer and Antiviral Activity Studies of 1,3,4-Oxadiazoles: A Review
Author(s) -
K Sarda Devi,
Srinivasa Rao Atla,
Y. Rajendra Prasad,
Kalyani Raju,
D. GEETA MOUNIKA
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23490
Subject(s) - chemistry , oxadiazole , lead compound , biological activity , kinase , pharmacology , computational biology , structure–activity relationship , combinatorial chemistry , biochemistry , in vitro , biology , organic chemistry
1,3,4-Oxadiazole is a five membered heterocyclic nucleus and a versatile lead structure, where its derivatives showed broad and potentbiological functions especially as anticancer and antiviral agents which are associated with various mechanisms such as inhibition ofdifferent enzymes, kinases and growth factors. The present review summarizes various synthetic procedures and highlights the targetedinhibitory activities of 1,3,4-oxadiazoles as potential anticancer and antiviral agents along with their structure activity relationship.Molecular modeling and pharmacokinetic studies on 1,3,4-oxadiazoles proved a change in their polarity, flexibility and metabolic stabilityled to their improved biological activity potential. Among all the substituted 1,3,4-oxadiazoles, the mono- and 2,5-disubstituted derivativesshowed considerable biological activities especially as anticancer and antiviral agents. Hence, scientists/researchers considered these asfuture lead molecules to treat cancer and viral infections along with other diseases. In future, the oxadiazole motif is likely to be incorporatedin various other therapeutic molecules.