Open AccessThiazolopyrimidines: A Retrospective Study of Synthesis, Structure-Activity Relationship and Diverse Pharmacological Actions
Author(s) -
Sameer Aggarwal,
Manish Devgun,
Rakesh Narang,
Sukhbir Lal Khokra,
Avtar Chand Rana,
Rajat Goyal
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23448
Subject(s) - chemistry , thiazole , pyrimidine , microwave irradiation , combinatorial chemistry , catalysis , nitrogen atom , sulfur , aromaticity , bicyclic molecule , nitrogen , carbon atom , yield (engineering) , antimicrobial , molecule , organic chemistry , stereochemistry , ring (chemistry) , materials science , metallurgy
Thiazolopyrimidine is a nitrogen and sulphur containing heterocyclic aromatic molecule. The bicyclic compound is made by fusing twoaromatic rings, thiazole and pyrimidine and replacing one carbon atom with nitrogen and sulphur. The current present work covers a widerange of methods for synthesizing thiazolopyrimidine and its derivatives using a variety of catalysts, solvent medium and microwaveirradiation with a goal of achieving a high yield and rapid separation of the product. This article describes the evolution of thiazolopyrimidineas antimicrobial, antiviral, anti-Parkinson, anticancer, anti-inflammatory as well as its structure-activity relationship and potential modeof action for future research. It also includes a list of current patents filed/granted linked to various pharmacological activities in theprevious few years.