Open AccessSynthesis, Characterization and Biological Evaluation of Novel Triazole Linked Chromone Biheterocycle Analogs
Author(s) -
Jilla Soujanya,
D. Ravisankar Reddy,
Gade Kalyani
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23420
Subject(s) - chromone , chemistry , ascorbic acid , antimicrobial , triazole , combinatorial chemistry , antifungal , biological activity , stereochemistry , potency , click chemistry , 1,2,4 triazole , organic chemistry , in vitro , biochemistry , medicine , food science , dermatology
The current work focused on the synthesis of novel chromone biheterocycle analogs followed by itscharacterization through physico-chemical and spectral techniques like FTIR, mass and NMRspectroscopy. The basic triazole heterocycle and its analogs have different biological properties. Atthe point when one biological active molecule is connected to another, the resultant shows improvedpotency (biheterocycles). Chromone and triazole are selected in this study to develop new efficient,simple, economically viable and biologically active synthetic compounds. All the novel derivatives oftriazole linked chromone biheterocycles were synthesized via a click chemistry procedure and screenedfor in vitro antimicrobial, antifungal and antioxidant studies. Among them, the compounds CRN-F(IC50 = 35.97), CRN-H (IC50 = 28.76) and CRN-J (IC50 = 29.72) have significant free radical scavengingactivity in comparison with the ascorbic acid as control standard (IC50 = 23.07). Some of these novelderivatives exhibited moderate antimicrobial and antifungal activity compared to that of the referencestandards. Hence, the novel chromone biheterocycle analogs played a protective role against oxidativedamage.