Open AccessAntimicrobial, Cytotoxicity and Molecular Docking Study of New Quinoline Schiff Base and its Metal(II) Complexes
Author(s) -
Baliram T. Vibhute,
B. D. Aghav,
B.P. More,
R.O. Bellamkonda,
Sanjay K. Patil
Publication year - 2022
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2022.23301
Subject(s) - chemistry , schiff base , quinoline , metal , cytotoxicity , antibacterial activity , docking (animal) , nuclear chemistry , ligand (biochemistry) , carbon 13 nmr , stereochemistry , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , bacteria , biochemistry , medicine , receptor , nursing , biology , in vitro , genetics
A new quinoline Schiff base ligand was synthesized by the reaction of 2-hydroxy-7-methylquinolin-3-carbaldehyde and 4-methylbenzene sulfonohydrazide. Synthesized Schiff base further utilized forthe formation of stable metal complexes with Cu(II), Ni(II), Co(II) and Cd(II) metal salts andcharacterized by different spectroscopic techniques i.e. 1H NMR, 13C NMR, FT-IR, UV-visible, ESR,MASS and TGA. The low molar conductance values indicate that synthesized metal(II) complexeswere non-electrolytes. The magnetic moment value indicates that Cu(II), Ni(II) and Co(II) complexeswere paramagnetic. Further, these compounds were screened for inhibition activity against four bacterialstrains, three fungal strains and cytotoxicity against the A-549 and MCF-7 cell lines by using the MTTmethod. Among the synthesized complexes, metal complexes exhibited excellent anticancer activityagainst the human lung cancer cell line (A-549). Schiff base and its Cd(II) complex showed goodantibacterial activity. Furthermore, molecular docking study shows the significant binding affinity ofmetal complexes with tubulin protein. Present study proposed that all the synthesized Schiff basemetal(II) complexes have excellent biological activity and could be act as potential anticancer agents.