Open AccessSynthesis and Evaluation of Antiepileptic Activity of Newly Designed Coumarin-Sulfonamide Hybrids
Author(s) -
Arti Gupta,
Sandeep Kumar,
Vijay Kumar Singh,
B.P. Mallikarjun,
Neerupma Dhiman,
Archana Sharma
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23527
Subject(s) - knoevenagel condensation , coumarin , sulfonamide , chemistry , moiety , ring (chemistry) , proton nmr , organic chemistry , stereochemistry , catalysis
The combination of different heterocyclic rings to form a multifunctional compound is a new approachto get the potent and selective compounds, which can act as antiepileptic drugs. In this study wedesigned and synthesized the hybrid of the coumarin ring with sulfonamide moiety. Coumarinsulfonamide hybrids (CS1-CS7) were synthesized by Knoevenagel condensation of methylanilinosulfonyl acetate with substituted salicyaldehyde in the presence of catalytic base. The synthesizedhybrid compounds were characterized by means of mass, 1H & 13C NMR and FTIR spectroscopy,moreover antiepileptic activity was screened through seizure model of epilepsy using pentylenetetrazoleand maximal electroshock. According to results, compound CS-2 remained to be highest potent andpresented significant protection at 60 mg/kg in both the seizure models. Furthermore, compoundCS-2 was also evaluated for biochemical and a histopathological study in which no significant resultswere obtained. In addition to former activities, compound CS-2 was also examined for liver toxicity.