Open AccessNovel Heterocyclic Transition Metal Complexes: Synthesis, Characterization, Antimicrobial and Anticancer Activity
Author(s) -
A.M. Anusuya,
Balam Satheesh Krishna,
S. Prasad,
K. Yogesh Kumar,
R. Raveesha,
M.K. Prashanth
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23519
Subject(s) - chemistry , ligand (biochemistry) , tetrahedral molecular geometry , deprotonation , denticity , metal , transition metal , stereochemistry , mtt assay , antibacterial activity , crystallography , medicinal chemistry , organic chemistry , in vitro , bacteria , ion , biochemistry , receptor , biology , genetics , catalysis
A heterocyclic ligand, 5-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)quinolin-8-ol and its Co(II),Ni(II), Cu(II) and Zn(II) complexes were synthesized and characterized by elemental analysis andspectroscopic techniques. According to the spectral analysis, the ligand acts as a bidentate ligand andcoordinating through the nitrogen and deprotonated oxygen atoms. For Cu(II) and Ni(II) complexes,spectral analysis reveals square planer geometry, whereas Co(II) and Zn(II) complexes have tetrahedralgeometry. The antibacterial results show that Zn(II) complex is more effective than the other metal(II)complexes examined. The ligand and its metal complexes were tested for anticancer activity using theMTT assay with cisplatin as the reference drug against A549, MCF7, and HCT116 cancer cell lines.Results showed that the metal(II) complexes were shown to be more active than the ligand, especiallyZn(II) complex being the most potent among this series.