Open AccessSynthetic Approach, Structural Performance and in vitro Antibacterial Activity: Nitrogen and Oxygen Donor Atoms containing Bidentate Schiff Base Ligand and its Mononuclear Complexation with Co(II) and Cu(II) Metal Ions
Author(s) -
RAVIKANT RAVIKANT,
Shweta Gautam,
Hament Kumar Rajor,
Poonam Pipil,
Jagvir Singh,
Sonica Singhal,
S. Sagar
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23491
Subject(s) - chemistry , denticity , schiff base , ligand (biochemistry) , antibacterial activity , octahedral molecular geometry , electron paramagnetic resonance , hydrazone , molar conductivity , metal , nuclear chemistry , metal ions in aqueous solution , chelation , inorganic chemistry , stereochemistry , organic chemistry , bacteria , biochemistry , nuclear magnetic resonance , physics , receptor , biology , genetics
A synthetic approach has been designed and followed for the synthesis of new bidentate Schiff baseligand 2-acetylthiophenenicotinic hydrazone (L) (which possessed nitrogen and oxygen donor atoms)and its Co(II) and Cu(II) mononuclear complexes. All the compounds were examined IR, 1H NMR,mass, EPR, conductivity, elemental analysis, etc. Octahedral geometry has been assigned to allsynthesized compounds on the basis of magnetic, IR and electronic spectral analysis. In vitro activityi.e. antibacterial (E. coli and P. aeruginosa) and antifungal (A. niger, M. phasolina and P. glomerata)had been examined for these compounds following well diffusion and poisoned food methods,respectively. During the performance of antifungal activity, antifungal agent was incorporated into themolten agar at various concentrations and mixed well. After performance of in vitro activity, it hasbeen resulted out that metal(II) complexes exhibited remarkable activity than free ligand but lessactive compared to the standard drugs..