Open AccessTheoretical Molecular Properties Prediction, Docking and Antimicrobial Studies on Anisidine-Isatin Schiff Bases
Author(s) -
G.K. Ayyadurai,
R. Jayaprakash,
S. Rathika
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23467
Subject(s) - isatin , chemistry , bacillus subtilis , antibacterial activity , docking (animal) , staphylococcus aureus , antimicrobial , staphylococcus epidermidis , combinatorial chemistry , schiff base , stereochemistry , bacteria , organic chemistry , medicine , genetics , nursing , biology
The continuous intake of a specific antibiotic for diseases is continuously reducing the immunity ofthe human in course of time, which includes Covid-19 treatment. Recent research on Schiff basesshows the promising biological activities and good antibacterial results. In this study, three Schiffbases with lactam ring using isatin and three different anisidines in presence of acetic acid weresynthesized and characterized. Drug likeness was examined using Molsoft and docking against thetarget proteins such as 5J6R, 3L9L, 5HVY, covid main protease and 3ZBO proteins for drug suitability.The experimental antibacterial activity against Gram-positive strains like Staphylococcus aureus,Bacillus subtilis and Staphylococcus epidermidis. Among the synthesized compounds, three Schiffbases ortho and meta substituted compounds exhibited good results when compared to para compound,where the methoxyl group position effect was observed.