Open AccessRecent Advances in Tetrazole Derivatives as Potential Antiviral Agents
Author(s) -
Ruchika Yogesh,
Nisheeth Srivastava
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23443
Subject(s) - tetrazole , pharmacophore , isostere , chemistry , moiety , combinatorial chemistry , computational biology , stereochemistry , biology
Viruses use the host cell’s biochemical machinery for replication and survival; and also undergomutations to evade the immune response and achieve better transmission. These features make itchallenging to develop selective drugs to kill viruses only and not the host cells. New and effectivepharmaceutical agents are required to overcome this challenge. Tetrazole moiety, as a bio-isostere ofcarboxylic acid/amide group, has been extensively used as a potent pharmacophore in severalbioactivities. Intrigued by the necessity of finding new antiviral compounds and tendency of tetrazolescaffolds to render various bioactivity profiles, this review article comprising literature reports oftetrazole-based synthetic compounds with promising antiviral activity is presented. This reviewcomprises significant literature reports from the scientific databases published during the past fourdecades. It is found that tetrazole based molecules are promising endeavor for the development ofpotential agents against influenza virus, HIV, HCV and other viruses.