Open AccessSyntheses, Characterization, Antimicrobial and DNA Cleavage Activity of Cr(III) Complexes with Coumarin based Schiff Base Ligands
Author(s) -
Rishi Kesh Meena,
Avnesh Kumari,
Neelu Sharma,
Nighat Fahmi
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23431
Subject(s) - chemistry , schiff base , coumarin , molar conductivity , carbon 13 nmr , chromium , metal , electron paramagnetic resonance , proton nmr , dna , semicarbazone , antimicrobial , stereochemistry , polymer chemistry , organic chemistry , nuclear magnetic resonance , biochemistry , physics
A series of biologically important complexes of chromium(III) have been synthesized by the reactionof 3-formyl-4-chlorocoumarin hydrazinecarbothioamide (L1H) and 3-formyl-4-chlorocoumarinhydrazinecarboxamide (L2H) with CrCl3·6H2O in 1:1 and 1:2 molar ratio. All the complexes havebeen characterized by elemental analysis, molecular weight determination, melting point, conductivitymeasurements, electronic, IR, 1H NMR, 13C NMR and EPR spectroscopic techniques and X-raydiffraction. In vitro biological screening effects of the compounds were tested against the pathogenicbacterial and fungal species. Further, free ligands and their metal complexes have been screened fortheir DNA cleavage activity. A comparative study of the biological activities of the Schiff base ligandsand their Cr(III) complexes indicates that the complexes exhibit higher antimicrobial and DNA cleavageactivity than the free ligands. Physico-chemical studies and spectral data suggested a hexa-coordinatedenvironment around the central metal ion.