Open AccessSynthesis, Characterization and Antimicrobial Activity Studies of Chlorocobaloximes with Neutral Bases Containing Amine Functionality
Author(s) -
Vijendran Vijaikanth,
S. Vasuki,
C. Immanuel David,
L. Chandran,
Sowmya Subramanian,
Murugan Sevanan
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23417
Subject(s) - chemistry , aniline , amine gas treating , bacteria , congo red , antimicrobial , acinetobacter baumannii , nuclear chemistry , staphylococcus aureus , gram negative bacteria , glycine , medicinal chemistry , organic chemistry , escherichia coli , biochemistry , amino acid , adsorption , pseudomonas aeruginosa , biology , genetics , gene
The inorganic cobaloximes of type [Co(Cl)(dmgH)2B]; where dmgH = dimethyl glyoxime and B =neutral bases: glycine, ethyl amine, 2-aminopyridine, 4-aminopyridine, 2,6-diaminopyridine, anilineand 1-napthylamine have been synthesized. The synthesized cobaloximes were characterized by IR,UV-visible, 1H NMR and 13C NMR spectroscopic techniques. The cobaloxime complexes were screenedfor their antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) andAcinetobacter baumannii by the zone of inhibition test, biofilm eradication on biomaterial using catheterand modified Congo red agar method. It has been found that the cobaloxime complexes exhibit inhibitionagainst both gram positive and gram negative bacteria and the cobaloximes showed better inhibitiontowards Gram-negative bacteria compared to Gram-positive bacteria.