Open AccessAntigout Potential of Selected Malaysian Traditional Vegetables/Ulam
Author(s) -
Nurul Syuhada Che Omar,
Fazleen Izzany Abu Bakar,
Mohd Fadzelly Abu Bakar,
Lim Sin Yee,
Maisarah Abdul Mutalib
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23412
Subject(s) - chemistry , phytochemical , centella , xanthine oxidase , ethyl acetate , traditional medicine , flavonoid , methanol , food science , antioxidant , chromatography , biochemistry , organic chemistry , enzyme , medicine
The discovery of pharmacologically active plant-derived natural products as an alternative approachis highly needed for the purpose of disease treatment, specifically in gout remedy. This study wasconducted to investigate the antigout potential of five selected Malaysian traditional vegetables/ulam,namely Gynura bicolor, Barringtonia racemosa, Centella asiatica, Manihot esculenta and Lasiaspinosa. n-Hexane, ethyl acetate and methanol extracts of the selected traditional vegetables/ulamwere analyzed for their xanthine oxidase inhibitory activity and phytochemical contents. The highesttotal phenolic and total flavonoid contents were observed in methanol extracts of L. spinosa and M.esculenta with the values of 1.68 ± 0.05 mg GAE/g and 1.26 ± 0.05 mg RE/g, respectively whereasmethanol extract of G. bicolor showed the highest total anthocyanin content. G. bicolor extracted inthree sequential solvents were found to possess the strongest xanthine oxidase inhibition with thelowest IC50 values. Therefore, the presence of phytochemical compounds in G. bicolor extracts mightcontribute to its antigout activity, suggesting this plant as antigout agent.