Open AccessSynthesis, Characterization and DNA Binding Studies of Some Hydrazide Derivatives Schiff Base Metal Complexes of Mn(II), Co(II/III), Ni(II), Cu(II) and Zn(II) Metal Ions
Author(s) -
Ramina,
Rajkumar Bhubon Singh,
Oinam U-wang
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23408
Subject(s) - chemistry , schiff base , triclinic crystal system , monoclinic crystal system , methylene , metal , crystallography , octahedron , metal ions in aqueous solution , carbohydrazide , molecule , crystal structure , inorganic chemistry , medicinal chemistry , organic chemistry
Eighteen metal complexes were synthesized by using four different Schiff base ligands,(1E)-1-((6-methyl-4-oxo-4H-chromen-3-yl)methylene)carbohydrazide (L1),6-[2-(salicylidene)hydrazinyl]-N′-(salicylidene)nicotinohydrazide (HL2), 6-hydrazinyl-N′-(6-methyl-4-oxo-4H-chromen-3-yl-methylene)nicotinohydrazide (HL3) and (E)-6-hydrazinyl-N′-(1-(2,3-dihydro-1,3-dioxo-1H-inden-2-yl)-ethylidene)pyridine-3-carbohydrazide (L4). Characterization of the metalcomplexes were carried out by using various physico-chemical techniques. Complexes 1, 3, 4, 6, 11, 14,15, 16, 17 and 18 have been found octahedral structures while the metal complexes 2, 5, 8, 10 and 13have tetrahedral structures. And, complexes 7, 9 and 12 have square planar structures. Thermal studyhas revealed the presence of lattice and coordinated water molecules in the complexes. From powderX-ray diffraction study, it was suggested that a monoclinic system for complexes 2 and 14 while atriclinic system for the complexes 3, 4, 5, 9, 11, 13 and 15. The interaction of the ligands and theirmetal complexes with calf thymus DNA (CT-DNA) has been studied by electronic absorption, cyclicvoltammetry and viscosity methods.