Open AccessMicrowave-Assisted Synthesis, Molecular Docking Studies and Biological Evaluation of Benzothiazole Containing Novel Indole Derivatives
Author(s) -
Shaheen Sultana,
P. Pandian,
B. Rajkamal
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23404
Subject(s) - benzothiazole , chemistry , isatin , indole test , schiff base , mannich base , combinatorial chemistry , docking (animal) , anthranilic acid , mannich reaction , biological activity , stereochemistry , organic chemistry , in vitro , biochemistry , catalysis , medicine , nursing
The synthesis of novel indole derivatives 4a-o using a microwave assisted method via Schiff’s baseand Mannich base reaction mechanism was described. Compounds 3a-c were synthesized via reactionof 2-amino benzothiazole with substituted isatin by Schiff base reaction mechanism. Also, indolederivatives 4a-o were synthesized via reaction of compounds 3a-c with substituted benzaldehydes byMannich base reaction. The biological potentials of the newly synthesized indole derivatives wereevaluated for their anthelmintic activity and in vitro anticancer activity by MTT assay. The anticanceractivity results suggested that indole derivatives 4c-o have activity against MCF-7 and SKOV3 cells incomparison with doxorubicin as standard drug. Furthermore, the molecular docking studies of thesenovel derivatives of indole showed good agreement with the biological results when their bindingpattern and affinity towards the active site of EGFR was also investigated.