Open AccessEco-Friendly Novel Synthesis, Characterization of 2,3-Disubstituted 4-Thiazolidinone Derivatives and their Antimicrobial Evaluations
Author(s) -
Ashutosh Pathak,
P. Malairajan,
Parmesh Kumar Dwivedi,
Devdutt Chaturvedi
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23399
Subject(s) - chemistry , thioglycolic acid , benzaldehyde , antimicrobial , benzene , organic chemistry , microwave irradiation , combinatorial chemistry , catalysis
A total of nine derivatives of 4-thiazolidinone were synthesized involving the reaction of benzene-1,2-diamine with 4-aminobenzoic acid followed by reaction with substituted benzaldehyde to get theSchiff bases. These synthesized Schiff bases were further reacted with thioglycolic acid to get thedesired thiazolidinones (29-37). In addition to conventional synthesis, the microwave irradiation methodhas also been employedfor the synthesis of these compounds which provides not only pollution freeand eco-friendly environment but also excellent yields. The results showed that 2-substitutedthiazolidinone derivatives exhibit good antibacterial activity. It was also recorded that the compoundscontaining -Cl, -NO2 group with thiazolidinone nucleus are more active than other compounds of thesynthesized series.