Open AccessSpectral and Electrochemical Sensing Studies of Unsymmetrical Schiff Bases having Enhanced Antifungal Activity
Author(s) -
Selvaraj Shunmugaperumal,
Saranya Dhasarathan,
K Selvaraj,
K. Ilango,
B. Siva Kumar
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23351
Subject(s) - chemistry , moiety , antifungal , metal ions in aqueous solution , imine , metal , schiff base , combinatorial chemistry , ferrocene , ion , quinoxaline , electrochemistry , photochemistry , polymer chemistry , stereochemistry , organic chemistry , electrode , medicine , dermatology , catalysis
Novel unsymmetrical Schiff bases comprising azomethine spin-off having ferrocene moiety at oneend and simple aromatic component attached imine at other end, capable of sensing multiple metalions have been synthesized. The MLCT charge transfer band in UV-Visible studies upon coordinationwith metal ions with receptors is recorded particularly for Cu2+ ions. The observed ΔEp values withchange in scan rate for metal free and metal added receptor solution suggest quasi-reversible process.Agar well diffusion method and molecular docking studies reveals that the synthesized compoundsinhibit more efficiently fungi rather than bacteria, which hampers the progress of microbial research,as the available antifungal agents are minimal compared to antibacterial counterpart.