Open AccessPhotophysical Studies on Drug Conjugates of Stavudine/Zidovudine and 1,8-Naphthalimide in Different Solvent Systems
Author(s) -
Nidhi Singh,
Farha Naaz,
Rajesh Verma,
Shivendra Singh,
R. K. P. Singh
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23348
Subject(s) - chemistry , stavudine , fluorescence , zidovudine , conjugate , dimethylformamide , reagent , solvent , aqueous solution , nuclear chemistry , solvatochromism , medicinal chemistry , combinatorial chemistry , photochemistry , human immunodeficiency virus (hiv) , organic chemistry , virology , biology , mathematical analysis , physics , mathematics , quantum mechanics , viral disease
A number of fluorescent conjugates of popular anti-HIV drugs 2′,3′-didehydro-2′,3′-dideoxythymidine(stavudine, d4T) and 3′-azido-3′-deoxythymidine (zidovudine, AZT) with 1,8-naphthalimide weresynthesized using the coupling reagent dicyclohexylcarbodiimide (DCC) in the presence of4-dimethylaminopyridine (DMAP) and N,N-dimethylformamide (DMF) as solvent at room temperature.The steady-state fluorescence measurement studies on these conjugates showed solvatochromic effect.Further, the fluorescence of drug conjugates was recorded in the presence of ions like Na+ and K+ atbody level concentration of 135-145 mmol L-1 and 3.6-5.1 mmol L-1, respectively, in phosphate bufferat pH 7.4 in aqueous media. It was observed that the drug conjugates did not show appreciablefluorescence quenching in presence of ions and buffer.