Open AccessPreparation of Polycaprolactone-Graphene Oxide Hydrogel as Potential Drug Delivery Carrier
Author(s) -
Juliet Q. Dalagan,
Higinio R. Barros
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23343
Subject(s) - polycaprolactone , graphene , swelling , oxide , fourier transform infrared spectroscopy , chemical engineering , scanning electron microscope , chemistry , drug delivery , composite number , nuclear chemistry , polymer chemistry , materials science , composite material , organic chemistry , polymer , engineering
Polycaprolactone-graphene oxide (PCL-GO) hydrogel composite was prepared using a facile methodand characterized by Fourier transform Infrared (FTIR) and scanning electron microscopy (SEM).The swelling capacity of the hydrogel at varying temperature and equilibration time was also determined.IR analysis revealed a shifting of bands, which indicates H-bonding interactions betweenpolycaprolactone and graphene oxide. Characteristic peaks of graphene oxide at 3500 cm-1 for -OHstretching and peaks of polycaprolactone at 1456, 1370, 1304 cm-1 for CH2 bending vibrations wereobserved. SEM images validated IR results with the occurrence of larger hollow regions, pores andinsets indicating reaction of OH groups with the polymeric chains. The swelling ratio of the PCL-GOhydrogel was higher than polycaprolactone and graphene oxide at 4 h and 8 h equilibration time. Theswelling ratio of PCL-GO at 40 ºC and 12 h equilibration time was 4.3, which was the highest amongthe swelling ratios. These data could imply that the PCL-GO prepared has the potential to be a potentialdrug carrier.