Open AccessDesign, Synthesis and Biological Evaluation of Novel Thiazolidinone Derivatives
Author(s) -
Reshma Sathyanarayana,
Boja Poojary,
B. Sukesh Kumar,
Vasantha Kumar,
Rajesh P. Shastry,
Shamprasad Varija Raghu
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23337
Subject(s) - chemistry , dpph , antibacterial activity , antioxidant , elemental analysis , pseudomonas aeruginosa , combinatorial chemistry , organic chemistry , bacteria , biology , genetics
In present study, the novel thiazolidinone derivatives were designed and synthesized. The formationof the target compounds was confirmed by the elemental analyses, FT-IR, mass spectroscopy and 1HNMR spectroscopy. These derivatives were subjected to antibacterial and antioxidant activities. Theantibacterial results revealed that these derivatives were selectively active against Gram-negativePseudomonas aeruginosa bacteria. Also, these derivatives displayed a good DPPH radical scavengingeffect. Drosophila melanogaster flies were used for evaluating the toxic impact of novel thiazolidinonederivatives.