Open AccessSynthesis of (E)-1-(2,4-Bis((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)- 3-phenylprop-2-en-1-one Derivatives and their Antimicrobial Activity
Author(s) -
Umapathi Nalla,
Jalapathi Pochampally,
M. Raghavender,
B. Shankar
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23320
Subject(s) - chemistry , bacillus cereus , antimicrobial , micrococcus luteus , proteus vulgaris , bacillus subtilis , microsporum gypseum , antibacterial activity , klebsiella pneumoniae , chalcone , epidermophyton floccosum , microbiology and biotechnology , stereochemistry , escherichia coli , organic chemistry , microsporum canis , bacteria , antifungal , biology , biochemistry , trichophyton , genetics , gene
A new series of chalcone based bis 1,4-disubstituted 1,2,3-triazole heterocyclic molecules (6a-j) weresynthesized via the reaction of 1-(2,4-bis((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethanone(6a-e) with substituted benzaldehyde. All the molecules were characterized by IR, 1H and 13C NMRand MS spectra spectral data. Compounds 6a-j were evaluated for their antimicrobial effects using abroth disc diffusion method. The compounds were evaluated for their in vitro antimicrobial potentialagainst Gram-positive (Micrococcus luteus, Methicillin-resistant Staphylococcus aureus, Bacillussubtilis and Bacillus cereus), Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae,Escherichia coli and Proteus vulgaris) bacterial and fungal (Microsporum canis, Microsporum gypseumand Epidermophyton floccosum) strains by comparison of the reference drugs, zentamycin sulphate(antibacterial) and nystatin (antifungal). The screened compounds 6f, 6e, 6c and 6i were found to bethe most active against all the tested bacterial and fungal strains.