Open AccessDetermination of Protonation Constants of Viral Inhibitor, Aurintricarboxylic Acid in SDS and CTAB Micellar Media: A Potentiometric Study
Author(s) -
K. Bhargavi,
P. Shyamala,
G. Nageswara Rao
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23318
Subject(s) - chemistry , potentiometric titration , aurintricarboxylic acid , protonation , ionic strength , micelle , cationic polymerization , stability constants of complexes , acid dissociation constant , ionic bonding , aqueous solution , inorganic chemistry , chromatography , analytical chemistry (journal) , ion , organic chemistry , apoptosis , biochemistry , programmed cell death
Protonation constants of a viral inhibitor, aurintricarboxylic acid were determined using potentiometricmethod of data acquisition followed by chemometric modelling methods of analysis in the presenceof two different kinds of micellar media, CTAB, a cationic micelle and SDS, an anionic micelle.MINIQUAD75 program was used for the determination of the plausible species and their correspondingformation constants at 303 ± 0.1 K and 0.01 M ionic strength. Five formation constants were identifiedcorresponding to five ionizable hydrogens. Species concentration distribution diagrams were generatedusing Origin software. Best-fit chemical models were selected on the basis of statistical parameterslike standard deviation (SD), U (sum of the squares of the residuals in mass balance equations) andchi-square test. It was found that the formation constants are lower in CTAB micellar medium whilethere is no significant change in the presence of SDS compared to aqueous medium.