Open AccessCharacterization, Molecular Docking, Antimicrobial and Anticancer Studies on 5-Bromo salicylaldehyde-furan-2-yl-methanamine Condensed Schiff Base Rare Earth Metal Complexes
Author(s) -
B. Preethi,
R. Jayaprakash,
S. Kutti Rani,
Natesan Vijayakumar
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23306
Subject(s) - chemistry , salicylaldehyde , schiff base , furan , metal , hela , docking (animal) , combinatorial chemistry , lanthanide , antimicrobial , rare earth , benzofuran , stereochemistry , antibacterial activity , organic chemistry , biochemistry , bacteria , mineralogy , medicine , ion , nursing , genetics , biology , cell
This work described the synthesis and characterization of 1-(furan-2-yl) methanamine condensedwith 5-bromo-2-hydroxybenzaldehyde Schiff base rare earth metal (Ln3+, Pr3+, Nd3+, Sm3+ and Eu3+)complexes.. They were characterized using relevant spectral techniques and docked against microbialtarget proteins (1H9Z, 3ZBO) theoretically. The experimental antibacterial and anticancer activities(HeLa, MCF7) of these metal complexes were investigated for biological efficacy. Out of five metalcomplexes, Pr3+ complex exposed good biological efficacy result in both assays.