Open AccessSynthesis, Characterization and in vitro Antimicrobial, Anticancer Activity of Random Copolyester using Orcinol
Author(s) -
T. Sivaramakrishnan,
Gandhi Elango
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23302
Subject(s) - copolyester , chemistry , polyester , orcinol , thermogravimetric analysis , condensation polymer , solubility , intrinsic viscosity , nuclear chemistry , polymer chemistry , polymer , organic chemistry
In present study, a novel random copolyester i.e. poly(3-oxy-5-methylphenyl-4-oxynaphthal-1-yl)isophthalate (PONI) was synthesized through solution polycondensation methodology involvingorcinol, 1,4-naphthalene diol and isophthaloyl chloride and its solubility in common solvents alongwith viscosity measurements were performed. The structure of the repeat units in the polyester chainwere ascertained based on the spectral characterization of UV-visible, FTIR, 1H & 13C NMR techniques.Thermal analysis of the copolyester were performed by TGA and DSC studies. The activation energyfor thermal decomposition of polyester was estimated by well-known kinetic methods. The surfacemorphology and crystalline nature of the polymer were explored by employing SEM and WAXDmethods. The antimicrobial efficacy of copolyester was assessed through well-diffusion method usinga Gram-positive and a Gram-negative bacteria. The in vitro cytotoxicity of the polyester prepared wasverified against HeLa cell line using MTT assay.