Open AccessAntibacterial Activity against Enterococcus faecium, Enterococcus faecalis and Inhibitory Activity of Monoamine Oxidase A & B by Persea americana “Avocado” Seed Extracts
Author(s) -
Noel-David Nogbou,
Z. T. Mkhombo,
M. T. Olivier,
Modupe O. Ogunrombi,
Rejoice B. Maseko,
Andrew Munyalo Musyoki
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23294
Subject(s) - enterococcus faecalis , phytochemical , antibacterial activity , chemistry , enterococcus faecium , monoamine oxidase , bacteria , antimicrobial , minimum inhibitory concentration , microbiology and biotechnology , traditional medicine , enzyme , biochemistry , biology , antibiotics , escherichia coli , organic chemistry , medicine , genetics , gene
This study reported various Persia americana seed extracts for the presence and total content ofphytochemicals, antibacterial activity and inhibitory activity against monoamine oxidase (MAO) A &B enzymes. Phytochemical studies showed that phenols, flavonoids and tannins were found in all thepolar solvents. The highest antibacterial activity was exhibited against Gram-positive bacteria by acetoneextract on Enterococcus faecium and methanol extract on Enterococcus faecalis. From the monoamineinhibition experiments, a significant inhibitory activity was observed from ethanolic extracts againstMAO-A and from n-hexane extracts against MAO-B. This study demonstrates the antimicrobial activityof P. americana seed extracts against enterococci bacteria, E. faecium and E. faecalis. This findingoffers hope of a potential new antibacterial compound in the treatment of these multidrug resistantbacteria.