Open AccessOxidation of Cinacalcet Hydrochloride by Chloramine-B in Acid Medium: A Kinetic and Mechanistic Study
Author(s) -
Nichhapurada Kallesha,
Ningegowda Prasad,
N. Shivakumara,
Kereyagalahally H. Narasimhamurthy
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23292
Subject(s) - chemistry , chloramine , arrhenius equation , stoichiometry , hydrochloride , kinetic energy , reaction rate , inorganic chemistry , activation energy , organic chemistry , catalysis , chlorine , physics , quantum mechanics
Kinetic and mechanistic study of cinacalcet hydrochloride by chloramine-B (CAB) in HCl medium at308 K was the aim of this work. Analyzed the reaction at five different temperatures and determinedthe thermodynamic parameters using Arrhenius plots. The reaction had a stoichiometry of 1:2 andcharacterized the oxidation product using chromatographic and spectroscopic methods. The rate lawis deduced from the marked effects, which were accompanied by plausible mechanisms.