Open AccessVegetable Oil-Based Self-Microemulsifying Drug Delivery System of Eprosartan Mesylate: in vitro and ex vivo Evaluation
Author(s) -
Sabitri Bindhani,
Snehamayee Mohapatra,
Rajat Kumar Kar
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23288
Subject(s) - chemistry , bioavailability , drug , drug delivery , pharmacology , pulmonary surfactant , chromatography , zeta potential , permeation , particle size , in vivo , ex vivo , in vitro , organic chemistry , nanotechnology , biochemistry , materials science , nanoparticle , medicine , microbiology and biotechnology , membrane , biology
This study was planned to increase the intestinal permeability and thereby bioavailability of eprosartanmesylate (EPM) by designing a self-microemulsifying drug delivery system (SMEDDS) by the use ofvegetable oils. Various SMEDDS-based formulations were prepared with oleic acid and peppermintoil. Tween 80 was used as surfactant and PEG 400 as co-surfactant. Pseudo ternary phase diagramswere constructed for identifying emulsification region between 1:1, 1:2, 2:1, 3:1 ratio of SCOS mix.Eight batches of SMEDDS were found to be thermodynamically stable and from which SMEDDSOF9and PF5 were best formulations due to their highest drug content, minimum particle size. They haveshown highest release of drug in vitro and higher in vitro drug diffusion and ex vivo permeationanalysis than pure drug. FTIR study ascertained no incompatibility between drug and excipients presentin formulation. From the accelerated stability study, slight effect on particle size and zeta potential,assay content along with cumulative % of drug release was found. The results demonstrated theSMEDDS of EPM are potent drug delivery system to increase dissolution rate and bioavailability ofdrug via increased intestinal permeability and consequently improving the therapeutic efficacy ofeprosartan mesylate.