Open AccessSynthesis, Characterization and Biological Evaluation of Metal(II) Complexes Containing Triphenylphosphine and Schiff Base Ligand Based on 3-Methoxysalicylaldehyde
Author(s) -
G. Gokulnath,
Panneerselvam Anitha,
R. Manikandan,
C. Umarani
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23262
Subject(s) - chemistry , schiff base , ligand (biochemistry) , triphenylphosphine , salicylaldehyde , metal , carbon 13 nmr , proton nmr , nuclear chemistry , polymer chemistry , stereochemistry , organic chemistry , biochemistry , receptor , catalysis
Schiff base ligand (HL) derived from condensation of 3-methoxy salicylaldehyde with 4-aminobenzoicacid and its metal(II) complexes containing triphenylphosphine of the type [MCl(PPh3)(L)] (M = Ni2+,Co2+ or Cu2+; L = bitendate Schiff base ligand) have been synthesized. All the metal(II) complexeswere characterized by analytical and spectroscopic (FT-IR, electronic, ESI-Mass, ESR, 1H, 13C NMRand 31P NMR) techniques. All the synthesized compounds were evaluated for in vitro antimicrobialefficiency against Gram-positive bacteria, Gram-negative bacteria and fungai using the agar welldiffusion method. Anticancer activity in vitro of the ligand and its metal(II) complexes were alsoscreened against MCF-7 cancer cell lines (human breast cancer cell line).