Open AccessSynthesis and Biological Screening of Pyrano[2,3-b]quinoline Derivatives
Author(s) -
M. Abirami,
S. Thamarai Selvi,
V. Nadaraj,
T. Daniel Thangadurai
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23253
Subject(s) - quinoline , knoevenagel condensation , chemistry , ionic liquid , microwave irradiation , antimicrobial , ethyl acetoacetate , condensation reaction , organic chemistry , ionic bonding , condensation , chemical synthesis , combinatorial chemistry , nuclear chemistry , catalysis , in vitro , biochemistry , ion , physics , thermodynamics
Herein, a novel ionic liquid catalyzed synthesis of 3-acetylpyrano[2,3-b]quinolin-2(1H)-ones (3a-e)from substituted 3-formylquinolin-2(1H)-ones (1a-e) and ethyl acetoacetate (2) through Knoevenagelcondensation is reported. We have perceived the application of microwave irradiation and ionic liquidfor carrying out pollution free and ecofriendly chemical reactions. These reactions proceeded muchfaster in ionic liquid medium under microwave irradiation. The structures of quinoline derivatives(3a-e) were characterized by standard physico-chemical techniques. The synthesized quinolinederivatives (3a-e) were also evaluated for their in vitro antimicrobial screening on different strains ofbacteria and fungi.