Open AccessSpectral, Theoretical and Biological Studies of 3-((4-Mercaptophenyl)imino)- 1-phenylindolin-2-one Schiff Base and Its Organotellurium(IV) Complexes
Author(s) -
Manish Kumar,
Poonam Jangra Darolia,
Nidhi Antil,
Mahak Dalal,
Jitender Kumar Narwal,
K. K. Verma,
Sapana Garg
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23214
Subject(s) - chemistry , schiff base , ligand (biochemistry) , octahedral molecular geometry , carbon 13 nmr , tellurium , octahedron , stereochemistry , proton nmr , medicinal chemistry , metal , crystallography , inorganic chemistry , organic chemistry , crystal structure , receptor , biochemistry
Schiff base ligand (3-((4-mercaptophenyl)imino)-1-phenylindolin-2-one) of 1-phenylindoline-2,3-dioneand 4-aminothiophenol was synthesized by refluxing. Organotellurium(IV) complexes of type(RTeCl3.NPhIATP and R2TeCl2.NPhIATP, where R = 4-hydroxyphenyl, 4-methoxyphenyl and3-methyl-4-hydroxyphenyl, NPhIATP = Schiff base ligand). The ligand and its organotellurium(IV)complexes (9a-f) were characterized by FT-IR, molar conductance, elemental analyses, UV-vis, mass,1H & 13C NMR spectral studies. Geometry of all the compounds were optimized and octahedral geometryhave been proposed for all the tellurium(IV) complexes. Molecular docking was studied to find thebinding interactions between ligand (NPhIATP) and receptor proteins: E. coli (3t88) and S. aureus(3ty7). The antimicrobial activity of ligand and its tellurium(IV) complexes have been screened againstbacteria and fungi. All the organotellurium(IV) complexes complexes showed good activity to ligandtowards different studied microorganisms.