Open AccessSynthesis, Biological Evaluation and Docking Studies of 1,2,4,5-Tetrasubstituted Imidazoles as Antibacterial Agents: Use of Niobia Supported Heteropoly Tungstate as an Efficient Reusable Catalyst
Author(s) -
Aravind Kurnool,
Karunasree Merugu,
Pachipulusu Shravya,
P. Malleswarareddya
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23181
Subject(s) - chemistry , tungstate , benzil , catalysis , combinatorial chemistry , amine gas treating , antibacterial activity , docking (animal) , ammonium acetate , aryl , organic chemistry , bacteria , alkyl , medicine , high performance liquid chromatography , nursing , biology , genetics
The synthesis of novel 1,2,4,5-tetrasubstituted imidazoles was carried out in a single molecular motifusing niobia supported heteropoly tungstate as a mild and efficient reusable catalyst. The condensationof 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde, aromatic amine, benzil, ammonium acetate andheteropoly tungstate supported on niobia was achieved under both conventional and non-conventionalconditions. The employed protocol provides significant advantages, as it exhibits a remarkable catalyticactivity on recovery, excellent yields and excellent reaction efficacy within short reaction times between1-2 h (conventional) and 1-3 min (microwave radiation). All the obtained compounds were characterizedby means of spectral data and elemental analysis. They were also screened for their antibacterial activity.To predict the binding mode of compounds with glutamine-fructose-6-phosphate transaminase (GlcN6Psynthase), docking studies were performed.