Open AccessStudy of Photophysico-chemical and Antimicrobial Photodynamic Properties of Visible Light Active Azometal(II) Complexes
Author(s) -
H.B. Teja,
H. S. Bhojya Naik,
Prashant Nayak,
M.C. Prabhakara
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23178
Subject(s) - chemistry , antimicrobial , octahedron , mtt assay , nuclear chemistry , in vitro , elemental analysis , ic50 , metal , cytotoxicity , octahedral molecular geometry , minimum inhibitory concentration , stereochemistry , visible spectrum , photodynamic therapy , inorganic chemistry , organic chemistry , biochemistry , physics , optoelectronics , crystal structure
The Co(II) and Mn(II) complexes with octahedral geometries of the type [Co(L)2(H2O)2] and[Mn(L)2(H2O)2] were synthesized and characterized by elemental analysis, FT-IR, UV-visible spectra,powered XRD and photoluminescence. Both metal(II) complexes were prepared with4-[(Z)-(8-hydroxyquinolin-5-yl)diazenyl]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one. Thecomplexes were evaluated for in vitro antimicrobial photodynamic activity against Gram-positive,Gram-negative bacteria and fungi. The cell inhibition rate was found to be 80-96%. in vitro Cytotoxicstudies were performed for the synthesized complexes against human melanoma (A-375) and humanprimary glioblastoma (U-87) cell lines by MTT assay where Co(II) complex showed potential inhibitoryefficiency with IC50 value of 115 μg/mL when compared to Mn(II) complex.