Open AccessSynthesis and Antimicrobial Evaluations of Sulfur Inserted Fluoro-Benzimidazoles
Author(s) -
Parmesh Kumar Dwivedi,
Devdutt Chaturvedi
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23174
Subject(s) - chemistry , antimicrobial , benzimidazole , triethylamine , sulfur , proton nmr , combinatorial chemistry , enterococcus faecalis , thiol , carbon 13 nmr , gram , bacteria , elemental analysis , thiazole , organic chemistry , stereochemistry , escherichia coli , biochemistry , genetics , biology , gene
A new series of fluorinated sulfur inserted benzimidazole analogues Za-i were synthesized andcharacterized. The new compounds were screened for their antimicrobial and antioxidant potential.The synthesized compounds were obtained by multiple step synthesis, initiating from the synthesis of5-(difluoromethoxy)-1H-benzimidazole-2-thiol X. The compounds Ya-i prepared by reacting differentlysubstituted anilines with chloroacetylchloride and triethylamine in DMF. Finally, the compound Xwas reacted with different derivatives of 2-chloro-N-phenylacetamide resulting in formation of titledcompounds Za-i. The synthesized compounds (Za-Zi) were characterized by spectral analysis viz.1H &13C NMR, mass spectra, elemental analysis and IR. The in vitro antimicrobial potential againstGram-positive (S. aureus and E. faecalis) and Gram-negative bacterial (E. coli and P.aeruginosa)strains as well as fungi (A. niger and C. albicans) was recorded for the obtained compounds. Some ofthe compounds exhibited encouraging results (in MIC) against Gram-positive and Gram-negativebacterial strains. These studies thus suggest that the designed sulfur inserted fluoro-benzimidazolesscaffold may serve as new promising template for further amplification as antimicrobial agents.