Open AccessSynthesis and Antimicrobial Activity of Cyclic Dithiocarbamates Employing Triton-B/CS2 System
Author(s) -
R.K. Vishnoi,
Sangeeta Bajpai,
Devdutt Chaturvedi,
Mukesh Shukla,
Ram Kishore,
Nitin Srivastava
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23173
Subject(s) - chemistry , antimicrobial , candida albicans , yield (engineering) , staphylococcus aureus , escherichia coli , in vitro , strain (injury) , combinatorial chemistry , elemental analysis , organic chemistry , bacteria , microbiology and biotechnology , biochemistry , medicine , materials science , genetics , gene , metallurgy , biology
An efficient and green methodology to synthesize cyclic dithiocarbamates (compounds 1-11) wasdeveloped by reaction of primary amines, CS2 and 1,2-dibromoethane or 1,4-dibromobutane, catalyzedby Triton-B (as PTC)/CS2 system. Mass spectroscopy, elemental analysis and 1H NMR are used forcharacterization of the synthesized compounds (1-11). This effectual green tactics give good yield ofproduct which entails mild conditions. Compounds (1-11) were found to possess in vitro antimicrobialactivities against the pathogenic bacterial and fungal strain. The microbial strains used to screen activitiesare Escherichia coli, Staphylococcus aureus and Candida albicans.