Open AccessIdentification, Isolation and Origin of Potential Dimer Impurities of Dichlorphenamide: A Carbonic Anhydrase Inhibitor Drug (Antiglaucoma)
Author(s) -
T. Purendar Reddy,
Nageshwar Dussa,
Srinivas Mamidi,
Mahesh Panasa,
Ramadas Chavakula,
M. Padma
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23166
Subject(s) - chemistry , dimer , impurity , drug , carbonic anhydrase i , sulfonyl , stereochemistry , combinatorial chemistry , enzyme , carbonic anhydrase , organic chemistry , pharmacology , medicine , alkyl
Present work describes the identification, isolation and characterization of two new process relateddimeric impurities of dichlorphenamide (1). During the synthesis of dichlorphenamide, the formationof two new dimeric impurities namely 2,3-dichloro-5-(3,4-dichloro-5-sulfamoyl-phenyl)sulfonylbenzenesulfonamide(2) (1,1Œ-dichlorphenamide dimer) and 2,3-dichloro-5-(2,3-dichloro-5-sulfamoylphenyl)sulfonyl-benzenesulfonamide (3) (1,3Œ-dichlorphenamide dimer) was observed. In addition,origin and the strategies adapted to control these potential dimer impurities were also described. Theseimpurities have a substantial impact on the quality of the drug substance as well as drug product.