Open AccessOne-Pot Solvent Free, Green Route to Novel Substituted Spiro[oxindole-isoxazolidine] Derivatives: Novel Candidates as Antimicrobial Agents
Author(s) -
Manpreet Kaur,
Sumeet Kaur Bhatia,
Baldev Singh
Publication year - 2021
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2021.23164
Subject(s) - oxindole , chemistry , isatin , antimicrobial , cycloaddition , maleimide , combinatorial chemistry , organic chemistry , environmentally friendly , green chemistry , yield (engineering) , condensation reaction , catalysis , reaction mechanism , ecology , materials science , metallurgy , biology
The environmentally benign catalyst and solvent-free synthesis of ketonitrones may not always beaccomplished by simple condensation reactions. The occasional reports of green synthetic routestoward these compounds have been reported. The key features of this 1,3-dipolar cycloaddition reactionsof N-[4-(-carboxycyclohexylmethyl)]maleimide with substituted isatin ketonitrone under microwaveconditions resulted in the green synthesis of series of novel fluoro-substitutedspiro[oxindole-isoxazolidine] derivatives in high yields, improved purity and short reaction times. Allthe synthesized compounds have been identified as potent in vitro antimicrobial agents. These resultspromoted the greener route to synthesize spiro[oxindole-isoxazolidine] derivatives with immensepharmacological importance in eco-friendly manner.